2dix: Difference between revisions

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New page: left|200px<br /> <applet load="2dix" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dix" /> '''Solution structure of the DSRM domain of Pr...
 
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[[Image:2dix.gif|left|200px]]<br />
<applet load="2dix" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dix" />
'''Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase'''<br />


==Disease==
==Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase==
Known diseases associated with this structure: Cone-rod dystrophy 11 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610362 610362]], Macular degeneration, age-related OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610362 610362]]
<StructureSection load='2dix' size='340' side='right'caption='[[2dix]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2dix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DIX FirstGlance]. <br>
2DIX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DIX OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dix OCA], [https://pdbe.org/2dix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dix RCSB], [https://www.ebi.ac.uk/pdbsum/2dix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dix ProSAT], [https://www.topsan.org/Proteins/RSGI/2dix TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN] Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:[https://omim.org/entry/612067 612067]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.<ref>PMID:18243799</ref> <ref>PMID:18420150</ref>
== Function ==
[https://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN] Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1.<ref>PMID:9687506</ref> <ref>PMID:10336432</ref> <ref>PMID:11238927</ref> <ref>PMID:16424907</ref> <ref>PMID:16982605</ref> <ref>PMID:17452327</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2dix_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dix ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Dang, W.]]
[[Category: Dang W]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: dsrm domain]]
[[Category: hypothetical protein prkra]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nmr]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: structure genomics]]
 
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Retrieved from "https://proteopedia.org/2dix"