1w4r: Difference between revisions
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New page: left|200px<br /> <applet load="1w4r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w4r, resolution 1.83Å" /> '''STRUCTURE OF A TYPE... |
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== | ==Structure of a type II thymidine kinase with bound dTTP== | ||
The structure of human cytosolic thymidine kinase in complex with its | <StructureSection load='1w4r' size='340' side='right'caption='[[1w4r]], [[Resolution|resolution]] 1.83Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1w4r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4r OCA], [https://pdbe.org/1w4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4r RCSB], [https://www.ebi.ac.uk/pdbsum/1w4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KITH_HUMAN KITH_HUMAN] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4r_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w4r ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications. | |||
Structure of a type II thymidine kinase with bound dTTP.,Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844<ref>PMID:15733844</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1w4r" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Birringer | [[Category: Birringer MS]] | ||
[[Category: Claus | [[Category: Claus MT]] | ||
[[Category: Folkers | [[Category: Folkers G]] | ||
[[Category: Kloer | [[Category: Kloer DP]] | ||
[[Category: Scapozza | [[Category: Scapozza L]] | ||
[[Category: Schulz | [[Category: Schulz GE]] | ||
Latest revision as of 08:22, 9 April 2025
Structure of a type II thymidine kinase with bound dTTP
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