2a79: Difference between revisions

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[[Image:2a79.gif|left|200px]]
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{{STRUCTURE_2a79|  PDB=2a79  |  SCENE=  }}
'''Mammalian Shaker Kv1.2 potassium channel- beta subunit complex'''


==Mammalian Shaker Kv1.2 potassium channel- beta subunit complex==
<StructureSection load='2a79' size='340' side='right'caption='[[2a79]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2a79]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A79 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a79 OCA], [https://pdbe.org/2a79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a79 RCSB], [https://www.ebi.ac.uk/pdbsum/2a79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a79 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/2a79_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a79 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.


==Overview==
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.,Long SB, Campbell EB, Mackinnon R Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7. PMID:16002581<ref>PMID:16002581</ref>
Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2A79 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A79 OCA].
</div>
<div class="pdbe-citations 2a79" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel., Long SB, Campbell EB, Mackinnon R, Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16002581 16002581]
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
[[Category: Protein complex]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Campbell, E B.]]
[[Category: Campbell EB]]
[[Category: Long, S B.]]
[[Category: Long SB]]
[[Category: MacKinnon, R.]]
[[Category: MacKinnon R]]
[[Category: Eukaryotic]]
[[Category: Ion channel]]
[[Category: Kv1 2]]
[[Category: Membrane protein]]
[[Category: Potassium channel]]
[[Category: Shaker]]
[[Category: Voltage dependent]]
[[Category: Voltage sensor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:41:54 2008''
Retrieved from "https://proteopedia.org/2a79"