2dp4: Difference between revisions

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New page: left|200px<br /> <applet load="2dp4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dp4, resolution 2.90Å" /> '''Crystal structure o...
 
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[[Image:2dp4.gif|left|200px]]<br />
<applet load="2dp4" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dp4, resolution 2.90&Aring;" />
'''Crystal structure of the complex formed between proteinase K and a human lactoferrin fragment at 2.9 A resolution'''<br />


==Disease==
==Crystal structure of the complex formed between proteinase K and a human lactoferrin fragment at 2.9 A resolution==
Known disease associated with this structure: Deafness, autosomal dominant 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602121 602121]]
<StructureSection load='2dp4' size='340' side='right'caption='[[2dp4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Parengyodontium_album Parengyodontium album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DP4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dp4 OCA], [https://pdbe.org/2dp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2dp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dp4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRTK_PARAQ PRTK_PARAQ] Hydrolyzes keratin at aromatic and hydrophobic residues.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/2dp4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dp4 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2DP4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Engyodontium_album Engyodontium album] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Peptidase_K Peptidase K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.64 3.4.21.64] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DP4 OCA].
*[[Proteinase 3D structures|Proteinase 3D structures]]
[[Category: Engyodontium album]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidase K]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Parengyodontium album]]
[[Category: Bhushan, A.]]
[[Category: Bhushan A]]
[[Category: Sharma, S.]]
[[Category: Sharma S]]
[[Category: Singh, A.K.]]
[[Category: Singh AK]]
[[Category: Singh, N.]]
[[Category: Singh N]]
[[Category: Singh, T.P.]]
[[Category: Singh TP]]
[[Category: lactoferrin fragment]]
[[Category: proteinase k]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:38:57 2007''

Latest revision as of 09:05, 6 November 2024

Crystal structure of the complex formed between proteinase K and a human lactoferrin fragment at 2.9 A resolution

2dp4, resolution 2.90Å

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