2e6o: Difference between revisions

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New page: left|200px<br /> <applet load="2e6o" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e6o" /> '''Solution structure of the HMG box domain fr...
 
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[[Image:2e6o.gif|left|200px]]<br />
<applet load="2e6o" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2e6o" />
'''Solution structure of the HMG box domain from human HMG-box transcription factor 1'''<br />


==About this Structure==
==Solution structure of the HMG box domain from human HMG-box transcription factor 1==
2E6O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E6O OCA].  
<StructureSection load='2e6o' size='340' side='right'caption='[[2e6o]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2e6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6O FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6o OCA], [https://pdbe.org/2e6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6o RCSB], [https://www.ebi.ac.uk/pdbsum/2e6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e6o TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBP1_HUMAN HBP1_HUMAN] Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.<ref>PMID:10958660</ref> <ref>PMID:10562551</ref> <ref>PMID:11500377</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6o_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e6o ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Qin, X.R.]]
[[Category: Qin XR]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: high mobility group box transcription factor 1]]
[[Category: hmg box containing protein 1]]
[[Category: hmg-box domain]]
[[Category: hmg-box transcription factor 1]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
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Retrieved from "https://proteopedia.org/2e6o"