2e6r: Difference between revisions
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New page: left|200px<br /> <applet load="2e6r" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e6r" /> '''Solution structure of the PHD domain in Smc... |
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== | ==Solution structure of the PHD domain in SmcY protein== | ||
<StructureSection load='2e6r' size='340' side='right'caption='[[2e6r]]' scene=''> | |||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[2e6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6R FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6r OCA], [https://pdbe.org/2e6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6r RCSB], [https://www.ebi.ac.uk/pdbsum/2e6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e6r TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KDM5D_HUMAN KDM5D_HUMAN] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.<ref>PMID:17320160</ref> <ref>PMID:17320162</ref> <ref>PMID:17351630</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6r_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e6r ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: He | [[Category: He F]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kadirvel | [[Category: Kadirvel S]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Muto | [[Category: Muto Y]] | ||
[[Category: Shirouzu M]] | |||
[[Category: Shirouzu | [[Category: Terada T]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 18:47, 29 May 2024
Solution structure of the PHD domain in SmcY protein
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