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New page: left|200px<br /> <applet load="2eaw" size="450" color="white" frame="true" align="right" spinBox="true" caption="2eaw, resolution 2.88Å" /> '''Human UMP Synthase ...
 
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[[Image:2eaw.gif|left|200px]]<br />
==Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)==
<applet load="2eaw" size="450" color="white" frame="true" align="right" spinBox="true"  
<StructureSection load='2eaw' size='340' side='right' caption='[[2eaw]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
caption="2eaw, resolution 2.88&Aring;" />
== Structural highlights ==
'''Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)'''<br />
<table><tr><td colspan='2'>[[2eaw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eaw OCA], [http://pdbe.org/2eaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eaw RCSB], [http://www.ebi.ac.uk/pdbsum/2eaw PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eaw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eaw ConSurf].
<div style="clear:both"></div>


==Disease==
==See Also==
Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
 
== References ==
==About this Structure==
<references/>
2EAW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EAW OCA].
__TOC__
[[Category: Homo sapiens]]
</StructureSection>
[[Category: Single protein]]
[[Category: Human]]
[[Category: Liu, Y.]]
[[Category: Liu, Y]]
[[Category: Pai, E.F.]]
[[Category: Pai, E F]]
[[Category: Tang, H.L.]]
[[Category: Tang, H L]]
[[Category: SO4]]
[[Category: C-terminal domain]]
[[Category: c-terminal domain]]
[[Category: Lyase]]
[[Category: human]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
[[Category: orotidine 5'-monophosphate decarboxylase]]
[[Category: Ump synthase]]
[[Category: ump synthase]]
 
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