2ec1: Difference between revisions
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New page: left|200px<br /> <applet load="2ec1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ec1" /> '''Solution structure of the RanBD1 domain fro... |
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== | ==Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa== | ||
<StructureSection load='2ec1' size='340' side='right'caption='[[2ec1]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ec1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec1 OCA], [https://pdbe.org/2ec1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ec1 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NUP50_HUMAN NUP50_HUMAN] Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.<ref>PMID:20016008</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec1_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ec1 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Kurosaki | [[Category: Kurosaki C]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | [[Category: Yoshida M]] | ||
[[Category: Yoshida | [[Category: Zhang HP]] | ||
[[Category: Zhang | |||
Latest revision as of 18:49, 29 May 2024
Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa
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