2edy: Difference between revisions

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New page: left|200px<br /> <applet load="2edy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2edy" /> '''Solution structures of the fn3 domain of hu...
 
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[[Image:2edy.gif|left|200px]]<br />
<applet load="2edy" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2edy" />
'''Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F'''<br />


==Disease==
==Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F==
Known disease associated with this structure: Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604763 604763]]
<StructureSection load='2edy' size='340' side='right'caption='[[2edy]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2edy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edy OCA], [https://pdbe.org/2edy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edy RCSB], [https://www.ebi.ac.uk/pdbsum/2edy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edy ProSAT], [https://www.topsan.org/Proteins/RSGI/2edy TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref>  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edy ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2EDY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EDY OCA].
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Harada T]]
[[Category: Harada, T.]]
[[Category: Kigawa T]]
[[Category: Kigawa, T.]]
[[Category: Koshiba S]]
[[Category: Koshiba, S.]]
[[Category: Sato M]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Watanabe S]]
[[Category: Sato, M.]]
[[Category: Yokoyama S]]
[[Category: Watanabe, S.]]
[[Category: Yokoyama, S.]]
[[Category: ec 3.1.3.48]]
[[Category: lar protein]]
[[Category: leukocyte antigen related]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: signaling protein]]
[[Category: structural genomics]]
 
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