2az2: Difference between revisions

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[[Image:2az2.gif|left|200px]]


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==Flock House virus B2-dsRNA Complex (P4122)==
The line below this paragraph, containing "STRUCTURE_2az2", creates the "Structure Box" on the page.
<StructureSection load='2az2' size='340' side='right'caption='[[2az2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2az2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZ2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
{{STRUCTURE_2az2|  PDB=2az2  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2az2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2az2 OCA], [https://pdbe.org/2az2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2az2 RCSB], [https://www.ebi.ac.uk/pdbsum/2az2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2az2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B2_FHV B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>


'''Flock House virus B2-dsRNA Complex (P4122)'''
==See Also==
 
*[[Flock house virus protein B2|Flock house virus protein B2]]
 
== References ==
==Overview==
<references/>
As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Flock House virus]]
2AZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA].
[[Category: Large Structures]]
 
[[Category: Chao JA]]
==Reference==
[[Category: Chapados BR]]
Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16228003 16228003]
[[Category: Debler EW]]
[[Category: Flock house virus]]
[[Category: Lee JH]]
[[Category: Single protein]]
[[Category: Schneemann A]]
[[Category: Chao, J A.]]
[[Category: Williamson JR]]
[[Category: Chapados, B R.]]
[[Category: Debler, E W.]]
[[Category: Lee, J H.]]
[[Category: Schneemann, A.]]
[[Category: Williamson, J R.]]
[[Category: Four-helix bundle]]
[[Category: Protein-rna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:39:02 2008''

Latest revision as of 09:14, 14 February 2024

Flock House virus B2-dsRNA Complex (P4122)

2az2, resolution 2.60Å

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