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New page: left|200px<br /> <applet load="2en2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2en2" /> '''Solution structure of the C2H2 type zinc fi...
 
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[[Image:2en2.gif|left|200px]]<br />
<applet load="2en2" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2en2" />
'''Solution structure of the C2H2 type zinc finger (region 598-626) of human B-cell lymphoma 6 protein'''<br />


==Disease==
==Solution structure of the C2H2 type zinc finger (region 598-626) of human B-cell lymphoma 6 protein==
Known diseases associated with this structure: Diabetes mellitus, neonatal, with congenital hypothyroidism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610192 610192]], Lymphoma, B-cell OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109565 109565]]
<StructureSection load='2en2' size='340' side='right'caption='[[2en2]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2en2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EN2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2en2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2en2 OCA], [https://pdbe.org/2en2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2en2 RCSB], [https://www.ebi.ac.uk/pdbsum/2en2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2en2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2en2 TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
== Function ==
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/en/2en2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2en2 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2EN2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2EN2 OCA].
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abe, H.]]
[[Category: Abe H]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Kobayashi, N.]]
[[Category: Kobayashi N]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Li, H.]]
[[Category: Li H]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Saito K]]
[[Category: Saito, K.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nmr]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: transcription]]
[[Category: zf-c2h2]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:51:57 2007''

Latest revision as of 18:52, 29 May 2024

Solution structure of the C2H2 type zinc finger (region 598-626) of human B-cell lymphoma 6 protein

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