2exe: Difference between revisions
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New page: left|200px<br /> <applet load="2exe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2exe, resolution 2.35Å" /> '''Crystal structure o... |
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== | ==Crystal structure of the phosphorylated CLK3== | ||
<StructureSection load='2exe' size='340' side='right'caption='[[2exe]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2exe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exe OCA], [https://pdbe.org/2exe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exe RCSB], [https://www.ebi.ac.uk/pdbsum/2exe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exe ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exe_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exe ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Ball | [[Category: Ball LJ]] | ||
[[Category: Bullock | [[Category: Bullock A]] | ||
[[Category: Das | [[Category: Das S]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Fedorov O]] | ||
[[Category: Fedorov | [[Category: Johansson C]] | ||
[[Category: Johansson | [[Category: Knapp S]] | ||
[[Category: Knapp | [[Category: Papagrigoriou E]] | ||
[[Category: Papagrigoriou | [[Category: Rellos P]] | ||
[[Category: Rellos | [[Category: Savitsky P]] | ||
[[Category: Sobott F]] | |||
[[Category: Savitsky | [[Category: Sundstrom M]] | ||
[[Category: Sobott | [[Category: Turnbull A]] | ||
[[Category: Sundstrom | [[Category: Ugochukwu E]] | ||
[[Category: Turnbull | [[Category: Weigelt J]] | ||
[[Category: Ugochukwu | [[Category: Von Delft F]] | ||
[[Category: | |||
[[Category: | |||
Latest revision as of 07:40, 23 August 2023
Crystal structure of the phosphorylated CLK3
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