2f25: Difference between revisions
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New page: left|200px<br /> <applet load="2f25" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f25, resolution 1.950Å" /> '''Crystal Structure ... |
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== | ==Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor== | ||
<StructureSection load='2f25' size='340' side='right'caption='[[2f25]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
[[ | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2f25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F25 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f25 OCA], [https://pdbe.org/2f25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f25 RCSB], [https://www.ebi.ac.uk/pdbsum/2f25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f25 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f25_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f25 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chavas | [[Category: Chavas LMG]] | ||
[[Category: Fusi | [[Category: Fusi P]] | ||
[[Category: Kato | [[Category: Kato R]] | ||
[[Category: Monti | [[Category: Monti E]] | ||
[[Category: Tettamanti | [[Category: Tettamanti G]] | ||
[[Category: Tringali | [[Category: Tringali C]] | ||
[[Category: Venerando | [[Category: Venerando B]] | ||
[[Category: Wakatsuki | [[Category: Wakatsuki S]] | ||
Latest revision as of 08:41, 4 June 2025
Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor
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