2bm6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2bm6.gif|left|200px]]


<!--
==The Structure of MfpA (Rv3361c, C2221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix.==
The line below this paragraph, containing "STRUCTURE_2bm6", creates the "Structure Box" on the page.
<StructureSection load='2bm6' size='340' side='right'caption='[[2bm6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2bm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BM6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene></td></tr>
{{STRUCTURE_2bm6|  PDB=2bm6 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bm6 OCA], [https://pdbe.org/2bm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bm6 RCSB], [https://www.ebi.ac.uk/pdbsum/2bm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bm6 ProSAT]</span></td></tr>
 
</table>
'''THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.'''
== Function ==
 
[https://www.uniprot.org/uniprot/O50390_MYCTO O50390_MYCTO]  
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/2bm6_consurf.spt"</scriptWhenChecked>
2BM6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BM6 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA., Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS, Science. 2005 Jun 3;308(5727):1480-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15933203 15933203]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bm6 ConSurf].
[[Category: Mycobacterium tuberculosis]]
<div style="clear:both"></div>
[[Category: Single protein]]
__TOC__
[[Category: Blanchard, J S.]]
</StructureSection>
[[Category: Hegde, S S.]]
[[Category: Large Structures]]
[[Category: Maxwell, A.]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Mitchenall, L A.]]
[[Category: Blanchard JS]]
[[Category: Roderick, S L.]]
[[Category: Hegde SS]]
[[Category: Takiff, H E.]]
[[Category: Maxwell A]]
[[Category: Vetting, M W.]]
[[Category: Mitchenall LA]]
[[Category: Dna gyrase]]
[[Category: Roderick SL]]
[[Category: Dna mimicry]]
[[Category: Takiff HE]]
[[Category: Pentapeptide repeat protein,fluroquinolone resistance]]
[[Category: Vetting MW]]
[[Category: Right-handed quadrilateral beta-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:28:46 2008''

Latest revision as of 06:38, 1 May 2024

The Structure of MfpA (Rv3361c, C2221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix.

2bm6, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2bm6&oldid=4135344"