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New page: left|200px<br /> <applet load="2fbe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fbe, resolution 2.52Å" /> '''Crystal Structure o...
 
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[[Image:2fbe.gif|left|200px]]<br />
<applet load="2fbe" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2fbe, resolution 2.52&Aring;" />
'''Crystal Structure of the PRYSPRY-domain'''<br />


==Overview==
==Crystal Structure of the PRYSPRY-domain==
We determined the first structure of PRYSPRY, a domain found in over 500, different proteins, involved in innate immune signaling, cytokine, signaling suppression, development, cell growth and retroviral, restriction. The fold encompasses a 7-stranded and a 6-stranded, antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds, to the concave surface of a donor molecule, which represents a putative, interaction site. Mutations in the PRYSPRY domains of Pyrin, which are, responsible for familial Mediterranean fever, map on the putative PRYSPRY, interaction site.
<StructureSection load='2fbe' size='340' side='right'caption='[[2fbe]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fbe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FBE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbe OCA], [https://pdbe.org/2fbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fbe RCSB], [https://www.ebi.ac.uk/pdbsum/2fbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fbe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RFPLA_HUMAN RFPLA_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/2fbe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fbe ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.


==About this Structure==
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.,Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311<ref>PMID:16364311</ref>
2FBE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FBE OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16364311 16364311]
</div>
<div class="pdbe-citations 2fbe" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Briand, C.]]
[[Category: Briand C]]
[[Category: Capitani, G.]]
[[Category: Capitani G]]
[[Category: Gruetter, C.]]
[[Category: Gruetter C]]
[[Category: Gruetter, M.G.]]
[[Category: Gruetter MG]]
[[Category: Mittl, P.R.]]
[[Category: Mittl PR]]
[[Category: dimer]]
[[Category: jellyroll beta-sandwich fold]]
 
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