2fc6: Difference between revisions

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New page: left|200px<br /> <applet load="2fc6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fc6" /> '''Solution structure of the zf-CCCH domain of...
 
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[[Image:2fc6.gif|left|200px]]<br />
<applet load="2fc6" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2fc6" />
'''Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)'''<br />


==About this Structure==
==Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)==
2FC6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA].  
<StructureSection load='2fc6' size='340' side='right'caption='[[2fc6]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc6 OCA], [https://pdbe.org/2fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc6 TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Pontocerebellar hypoplasia type 7. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).<ref>PMID:12562764</ref> <ref>PMID:28092684</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Dang, W.]]
[[Category: Dang W]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: member 1(nuclear)]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nmr]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: structure genomics]]
[[Category: target of egr1]]
[[Category: zf-ccch domain]]
 
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