2g2b: Difference between revisions

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New page: left|200px<br /> <applet load="2g2b" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g2b" /> '''NMR structure of the human allograft inflam...
 
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[[Image:2g2b.gif|left|200px]]<br />
<applet load="2g2b" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2g2b" />
'''NMR structure of the human allograft inflammatory factor 1'''<br />


==Disease==
==NMR structure of the human allograft inflammatory factor 1==
Known disease associated with this structure: Polycystic liver disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=177060 177060]]
<StructureSection load='2g2b' size='340' side='right'caption='[[2g2b]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2g2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2B FirstGlance]. <br>
2G2B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2b OCA], [https://pdbe.org/2g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2b RCSB], [https://www.ebi.ac.uk/pdbsum/2g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2b ProSAT], [https://www.topsan.org/Proteins/CESG/2g2b TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AIF1_HUMAN AIF1_HUMAN] Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.<ref>PMID:15117732</ref> <ref>PMID:16049345</ref> <ref>PMID:18699778</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/2g2b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g2b ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: CESG, Center.for.Eukaryotic.Structural.Genomics.]]
[[Category: Markley JL]]
[[Category: Markley, J.L.]]
[[Category: Newman CL]]
[[Category: Newman, C.L.]]
[[Category: Song J]]
[[Category: Song, J.]]
[[Category: Tyler RC]]
[[Category: Tyler, R.C.]]
[[Category: Vinarov D]]
[[Category: Vinarov, D.]]
[[Category: aif-1]]
[[Category: allograft inflammatory factor 1]]
[[Category: center for eukaryotic structural genomics]]
[[Category: cesg]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomics]]
 
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Retrieved from "https://proteopedia.org/2g2b"