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[[Image:2cky.gif|left|200px]]
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{{STRUCTURE_2cky|  PDB=2cky  |  SCENE=  }}
'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''


==Structure of the Arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand==
<StructureSection load='2cky' size='340' side='right'caption='[[2cky]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cky OCA], [https://pdbe.org/2cky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cky RCSB], [https://www.ebi.ac.uk/pdbsum/2cky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cky ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.


==Overview==
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.,Thore S, Leibundgut M, Ban N Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665<ref>PMID:16675665</ref>
Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2CKY is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA].
</div>
<div class="pdbe-citations 2cky" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16675665 16675665]
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
[[Category: Single protein]]
== References ==
[[Category: Ban, N.]]
<references/>
[[Category: Leibundgut, M.]]
__TOC__
[[Category: Thore, S.]]
</StructureSection>
[[Category: Nucleic acid]]
[[Category: Arabidopsis thaliana]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:23:22 2008''
[[Category: Large Structures]]
[[Category: Ban N]]
[[Category: Leibundgut M]]
[[Category: Thore S]]

Latest revision as of 09:26, 9 May 2024

Structure of the Arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand

2cky, resolution 2.90Å

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