2g6p: Difference between revisions

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New page: left|200px<br /> <applet load="2g6p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g6p, resolution 1.90Å" /> '''Crystal structure o...
 
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[[Image:2g6p.gif|left|200px]]<br />
<applet load="2g6p" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2g6p, resolution 1.90&Aring;" />
'''Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative'''<br />


==About this Structure==
==Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative==
2G6P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO, K, HM2, EPE and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G6P OCA].  
<StructureSection load='2g6p' size='340' side='right'caption='[[2g6p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2g6p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G6P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HM2:5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE'>HM2</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6p OCA], [https://pdbe.org/2g6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g6p RCSB], [https://www.ebi.ac.uk/pdbsum/2g6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g6p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g6p ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases., Hu X, Addlagatta A, Matthews BW, Liu JO, Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3772-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16724298 16724298]
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Methionyl aminopeptidase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Addlagatta A]]
[[Category: Addlagatta, A.]]
[[Category: Hu X]]
[[Category: Hu, X.]]
[[Category: Liu JO]]
[[Category: Liu, J.O.]]
[[Category: Matthews BW]]
[[Category: Matthews, B.W.]]
[[Category: CO]]
[[Category: EPE]]
[[Category: GOL]]
[[Category: HM2]]
[[Category: K]]
[[Category: hydrolase]]
[[Category: methionine aminopeptidase]]
[[Category: pyridinyl pyrimidine]]
 
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Retrieved from "https://proteopedia.org/2g6p"