2g76: Difference between revisions

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New page: left|200px<br /> <applet load="2g76" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g76, resolution 1.70Å" /> '''Crystal structure o...
 
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[[Image:2g76.gif|left|200px]]<br />
<applet load="2g76" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2g76, resolution 1.70&Aring;" />
'''Crystal structure of human 3-phosphoglycerate dehydrogenase'''<br />


==Disease==
==Crystal structure of human 3-phosphoglycerate dehydrogenase==
Known disease associated with this structure: Phosphoglycerate dehydrogenase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606879 606879]]
<StructureSection load='2g76' size='340' side='right'caption='[[2g76]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2g76]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G76 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [https://pdbe.org/2g76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB], [https://www.ebi.ac.uk/pdbsum/2g76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g76 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
== Function ==
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g76_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g76 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2G76 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MLT and NAD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA].
*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoglycerate dehydrogenase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Edwards A]]
[[Category: Delft, F.von.]]
[[Category: Gileadi O]]
[[Category: Edwards, A.]]
[[Category: Oppermann U]]
[[Category: Gileadi, O.]]
[[Category: Salah E]]
[[Category: Oppermann, U.]]
[[Category: Savitsky P]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Sundstrom M]]
[[Category: Salah, E.]]
[[Category: Turnbull AP]]
[[Category: Savitsky, P.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Turnbull, A.P.]]
[[Category: Weigelt, J.]]
[[Category: MLT]]
[[Category: NAD]]
[[Category: 2-hydroxyacid dehydrogenases]]
[[Category: oxidoreductase]]
[[Category: phosphoglycerate dehydrogenase deficiency]]
[[Category: serine metabolism]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:15:48 2007''

Latest revision as of 09:36, 30 August 2023

Crystal structure of human 3-phosphoglycerate dehydrogenase

2g76, resolution 1.70Å

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