2cr7: Difference between revisions

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[[Image:2cr7.gif|left|200px]]


<!--
==Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B==
The line below this paragraph, containing "STRUCTURE_2cr7", creates the "Structure Box" on the page.
<StructureSection load='2cr7' size='340' side='right'caption='[[2cr7]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2cr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr7 OCA], [https://pdbe.org/2cr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr7 TOPSAN]</span></td></tr>
{{STRUCTURE_2cr7|  PDB=2cr7  |  SCENE= }}
</table>
 
== Function ==
'''Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B'''
[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2CR7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cr7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cr7 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Hayashi F]]
[[Category: Hayashi, F.]]
[[Category: Nagashima K]]
[[Category: Nagashima, K.]]
[[Category: Yokoyama S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yoshida M]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida, M.]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Paired amphipathic helix repeat]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Transcriptional repressor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:51:48 2008''

Latest revision as of 11:29, 22 May 2024

Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B

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