2gal: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /> <applet load="2gal" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gal, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2gal.gif|left|200px]]<br />
<applet load="2gal" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2gal, resolution 2.00&Aring;" />
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE'''<br />


==Overview==
==CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE==
Knowledge about carbohydrate recognition domains of galectins, formerly, known as S-type animal lectins, is important in understanding their, role(s) in cell-cell interactions. Here we report the crystal structure of, human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This, is the first structure of a galectin determined in both free and, carbohydrate-bound forms. The structure shows a fold similar to that of, the prototype galectins -1 and -2, but has greater similarity to a related, galectin molecule, Gal-10. Even though the carbohydrate-binding residues, are conserved, there are significant changes in this pocket due to, shortening of a loop structure. The monomeric hGal-7 molecule exists as a, dimer in the crystals, but adopts a packing arrangement considerably, different from that of Gal-1 and Gal-2, which has implications for, carbohydrate recognition.
<StructureSection load='2gal' size='340' side='right'caption='[[2gal]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GAL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gal OCA], [https://pdbe.org/2gal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gal RCSB], [https://www.ebi.ac.uk/pdbsum/2gal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gal ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG7_HUMAN LEG7_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/2gal_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gal ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2GAL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GAL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GAL OCA].
*[[Galectin 3D structures|Galectin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9760227 9760227]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Acharya, K.R.]]
[[Category: Acharya KR]]
[[Category: Leonidas, D.D.]]
[[Category: Leonidas DD]]
[[Category: GAL]]
[[Category: carbohydrate binding]]
[[Category: galaptin]]
[[Category: galectin]]
[[Category: lectin]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:16:46 2007''

Latest revision as of 09:26, 14 February 2024

CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE

2gal, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2gal&oldid=4058647"