2gf0: Difference between revisions

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New page: left|200px<br /> <applet load="2gf0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gf0, resolution 1.90Å" /> '''The crystal structu...
 
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[[Image:2gf0.gif|left|200px]]<br />
<applet load="2gf0" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2gf0, resolution 1.90&Aring;" />
'''The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state'''<br />


==Disease==
==The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state==
Known disease associated with this structure: Gaze palsy, horizontal, with progressive scoliosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608630 608630]]
<StructureSection load='2gf0' size='340' side='right'caption='[[2gf0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GF0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gf0 OCA], [https://pdbe.org/2gf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2gf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gf0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DIRA1_HUMAN DIRA1_HUMAN] Displays low GTPase activity and exist predominantly in the GTP-bound form.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/2gf0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gf0 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2GF0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GF0 OCA].
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Delft, F.von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Fedorov O]]
[[Category: Fedorov, O.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Niesen FE]]
[[Category: Niesen, F.E.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Salah E]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Schoch G]]
[[Category: Salah, E.]]
[[Category: Sundstrom M]]
[[Category: Schoch, G.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Turnbull, A.P.]]
[[Category: Wen-Hwa L]]
[[Category: Weigelt, J.]]
[[Category: Yang X]]
[[Category: Wen-Hwa, L.]]
[[Category: Von Delft F]]
[[Category: Yang, X.]]
[[Category: GDP]]
[[Category: MG]]
[[Category: diras]]
[[Category: gdp/gtp binding]]
[[Category: gtp hydrolysis]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:18:00 2007''
Retrieved from "https://proteopedia.org/2gf0"