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New page: left|200px<br /> <applet load="2gjs" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gjs, resolution 1.90Å" /> '''The crystal structu...
 
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[[Image:2gjs.gif|left|200px]]<br />
<applet load="2gjs" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2gjs, resolution 1.90&Aring;" />
'''The crystal structure of human RRAD in complex with GDP'''<br />


==Disease==
==The crystal structure of human RRAD in complex with GDP==
Known disease associated with this structure: Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179617 179617]]
<StructureSection load='2gjs' size='340' side='right'caption='[[2gjs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjs OCA], [https://pdbe.org/2gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjs RCSB], [https://www.ebi.ac.uk/pdbsum/2gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjs ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2GJS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA].
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berridge, G.]]
[[Category: Berridge G]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Debreczeni, J.]]
[[Category: Debreczeni J]]
[[Category: Delft, F.von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins JM]]
[[Category: Elkins, J.M.]]
[[Category: Gileadi C]]
[[Category: Gileadi, C.]]
[[Category: Pantic N]]
[[Category: Pantic, N.]]
[[Category: Schoch G]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Smee CEA]]
[[Category: Schoch, G.]]
[[Category: Soundararajan M]]
[[Category: Smee, C.E.A.]]
[[Category: Sundstrom M]]
[[Category: Soundararajan, M.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Turnbull, A.P.]]
[[Category: Yang X]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Yang, X.]]
[[Category: GDP]]
[[Category: MG]]
[[Category: gdp/gtp binding]]
[[Category: gtp hydrolysis]]
[[Category: rrad]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
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Retrieved from "https://proteopedia.org/2gjs"