2db8: Difference between revisions

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[[Image:2db8.gif|left|200px]]


<!--
==Solution structures of the fn3 domain of human Tripartite motif protein 9==
The line below this paragraph, containing "STRUCTURE_2db8", creates the "Structure Box" on the page.
<StructureSection load='2db8' size='340' side='right'caption='[[2db8]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2db8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DB8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2db8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2db8 OCA], [https://pdbe.org/2db8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2db8 RCSB], [https://www.ebi.ac.uk/pdbsum/2db8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2db8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2db8 TOPSAN]</span></td></tr>
{{STRUCTURE_2db8|  PDB=2db8  |  SCENE= }}
</table>
 
== Function ==
'''Solution structures of the fn3 domain of human Tripartite motif protein 9'''
[https://www.uniprot.org/uniprot/TRIM9_HUMAN TRIM9_HUMAN] E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.<ref>PMID:20085810</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2DB8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DB8 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2db8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2db8 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Kiaa0282]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Ring finger protein 91]]
[[Category: Rnf91]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Trim9]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:05:04 2008''

Latest revision as of 11:37, 22 May 2024

Solution structures of the fn3 domain of human Tripartite motif protein 9

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