2dhb: Difference between revisions

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[[Image:2dhb.gif|left|200px]]


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==THREE DIMENSIONAL FOURIER SYNTHESIS OF HORSE DEOXYHAEMOGLOBIN AT 2.8 ANGSTROMS RESOLUTION==
The line below this paragraph, containing "STRUCTURE_2dhb", creates the "Structure Box" on the page.
<StructureSection load='2dhb' size='340' side='right'caption='[[2dhb]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2dhb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. The May 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemoglobin''  by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_5 10.2210/rcsb_pdb/mom_2003_5]. The October 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''PDB Pioneers''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_10 10.2210/rcsb_pdb/mom_2011_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_2dhb| PDB=2dhb |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhb OCA], [https://pdbe.org/2dhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhb RCSB], [https://www.ebi.ac.uk/pdbsum/2dhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBA_HORSE HBA_HORSE] Involved in oxygen transport from the lung to the various peripheral tissues.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dhb ConSurf].
<div style="clear:both"></div>


'''THREE DIMENSIONAL FOURIER SYNTHESIS OF HORSE DEOXYHAEMOGLOBIN AT 2.8 ANGSTROMS RESOLUTION'''
==See Also==
 
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2DHB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dhb 1dhb]. The following page contains interesting information on the relation of 2DHB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html Hemoglobin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHB OCA].
 
==Reference==
Three dimensional fourier synthesis of horse deoxyhaemoglobin at 2.8 Angstrom units resolution., Bolton W, Perutz MF, Nature. 1970 Nov 7;228(5271):551-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/5472471 5472471]
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Hemoglobin]]
[[Category: Hemoglobin]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Al., M F.Perutz et.]]
[[Category: PDB Pioneers]]
[[Category: Oxygen transport]]
[[Category: RCSB PDB Molecule of the Month]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:25:50 2008''
[[Category: Perutz MF]]
Retrieved from "https://proteopedia.org/2dhb"