2dlr: Difference between revisions
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< | ==Solution structure of the RGS domain of human Regulator of G-protein signaling 10== | ||
<StructureSection load='2dlr' size='340' side='right'caption='[[2dlr]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2dlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlr OCA], [https://pdbe.org/2dlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlr RCSB], [https://www.ebi.ac.uk/pdbsum/2dlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlr ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlr TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RGS10_HUMAN RGS10_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dlr_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dlr ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Nagashima | [[Category: Nagashima T]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | [[Category: Zhang HP]] | ||
[[Category: Zhang | |||
Latest revision as of 18:43, 29 May 2024
Solution structure of the RGS domain of human Regulator of G-protein signaling 10
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