2hhl: Difference between revisions
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New page: left|200px<br /> <applet load="2hhl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hhl, resolution 2.100Å" /> '''Crystal structure ... |
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== | ==Crystal structure of the human small CTD phosphatase 3 isoform 1== | ||
<StructureSection load='2hhl' size='340' side='right'caption='[[2hhl]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
[[ | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HHL FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hhl OCA], [https://pdbe.org/2hhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hhl RCSB], [https://www.ebi.ac.uk/pdbsum/2hhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hhl ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hhl TOPSAN]</span></td></tr> | |||
</table> | |||
== Evolutionary Conservation == | |||
[ | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
[ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/2hhl_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
[ | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hhl ConSurf]. | |||
<div style="clear:both"></div> | |||
[[ | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | |||
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases. | |||
[ | |||
[[ | |||
[ | |||
Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2hhl" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Adams JM]] | |||
[[Category: Almo SC]] | |||
[[Category: Atwell S]] | |||
[[Category: Bain KT]] | |||
[[Category: Boice A]] | |||
[[Category: Burley SK]] | |||
[[Category: Dickey M]] | |||
[[Category: Emtage S]] | |||
[[Category: Gheyi T]] | |||
[[Category: Groshong C]] | |||
[[Category: Malashkevich VN]] | |||
[[Category: Ozyurt S]] | |||
[[Category: Powell A]] | |||
[[Category: Ramagopal U]] | |||
[[Category: Reyes C]] | |||
[[Category: Rooney I]] | |||
[[Category: Rutter ME]] | |||
[[Category: Sauder JM]] | |||
[[Category: Schwinn KD]] | |||
[[Category: Thompson DA]] | |||
[[Category: Toro R]] | |||
[[Category: Wasserman SR]] | |||
Latest revision as of 08:11, 13 August 2026
Crystal structure of the human small CTD phosphatase 3 isoform 1
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