2hlz: Difference between revisions

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New page: left|200px<br /> <applet load="2hlz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hlz, resolution 1.850Å" /> '''Crystal Structure ...
 
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[[Image:2hlz.gif|left|200px]]<br />
<applet load="2hlz" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2hlz, resolution 1.850&Aring;" />
'''Crystal Structure of human ketohexokinase (CASP Target)'''<br />


==Disease==
==Crystal Structure of human ketohexokinase==
Known disease associated with this structure: Fructosuria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=229800 229800]]
<StructureSection load='2hlz' size='340' side='right'caption='[[2hlz]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2hlz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HLZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlz OCA], [https://pdbe.org/2hlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hlz RCSB], [https://www.ebi.ac.uk/pdbsum/2hlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hlz ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/2hlz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hlz ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2HLZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with UNX as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ketohexokinase Ketohexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.3 2.7.1.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HLZ OCA].
*[[Ketohexokinase|Ketohexokinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ketohexokinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C.H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A.M.]]
[[Category: Landry R]]
[[Category: Landry, R.]]
[[Category: Nedyalkova L]]
[[Category: Nedyalkova, L.]]
[[Category: Park H]]
[[Category: Park, H.]]
[[Category: Rabeh WM]]
[[Category: Rabeh, W.M.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Tempel W]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Tempel, W.]]
[[Category: Weigelt, J.]]
[[Category: UNX]]
[[Category: creatine kinase]]
[[Category: fructokinase]]
[[Category: isoform a]]
[[Category: non-protein kinase]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:34:04 2007''
Retrieved from "https://proteopedia.org/2hlz"