2ed0: Difference between revisions

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[[Image:2ed0.jpg|left|200px]]


<!--
==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)==
The line below this paragraph, containing "STRUCTURE_2ed0", creates the "Structure Box" on the page.
<StructureSection load='2ed0' size='340' side='right'caption='[[2ed0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [https://pdbe.org/2ed0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr>
{{STRUCTURE_2ed0|  PDB=2ed0  |  SCENE= }}
</table>
 
== Function ==
'''Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)'''
[https://www.uniprot.org/uniprot/ABI2_HUMAN ABI2_HUMAN] May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.<ref>PMID:7590236</ref> <ref>PMID:8649853</ref> <ref>PMID:10498863</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2ED0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2ed0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ed0 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abe, H.]]
[[Category: Abe H]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Miyamoto, K.]]
[[Category: Miyamoto K]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Saito K]]
[[Category: Saito, K.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Coiled coil]]
[[Category: Cytoskeleton]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nuclear protein]]
[[Category: Phosphorylation]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Sh3 domain]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 02:21:00 2008''

Latest revision as of 18:49, 29 May 2024

Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)

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