2i5f: Difference between revisions

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New page: left|200px<br /> <applet load="2i5f" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i5f, resolution 1.35Å" /> '''Crystal structure o...
 
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[[Image:2i5f.gif|left|200px]]<br />
<applet load="2i5f" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2i5f, resolution 1.35&Aring;" />
'''Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,5,6)P5'''<br />


==Disease==
==Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,5,6)P5==
Known disease associated with this structure: Age-related maculopathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607772 607772]]
<StructureSection load='2i5f' size='340' side='right'caption='[[2i5f]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2i5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I5F FirstGlance]. <br>
2I5F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 5IP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2I5F OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IP:(1R,2R,3R,4R,5S,6S)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL+PENTAKIS[DIHYDROGEN+(PHOSPHATE)]'>5IP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i5f OCA], [https://pdbe.org/2i5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i5f RCSB], [https://www.ebi.ac.uk/pdbsum/2i5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i5f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLEK_HUMAN PLEK_HUMAN] Major protein kinase C substrate of platelets.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/2i5f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i5f ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Haslam, R.J.]]
[[Category: Haslam RJ]]
[[Category: Jackson, S.G.]]
[[Category: Jackson SG]]
[[Category: Junop, M.S.]]
[[Category: Junop MS]]
[[Category: 5IP]]
[[Category: lipid binding protein]]
[[Category: ph domain]]
[[Category: protein-inositol phosphate complex]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:41:19 2007''
Retrieved from "https://proteopedia.org/2i5f"