2fho: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2fho.jpg|left|200px]]


<!--
==NMR solution structure of the human spliceosomal protein complex p14-SF3b155==
The line below this paragraph, containing "STRUCTURE_2fho", creates the "Structure Box" on the page.
<StructureSection load='2fho' size='340' side='right'caption='[[2fho]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2fho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FHO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fho OCA], [https://pdbe.org/2fho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fho RCSB], [https://www.ebi.ac.uk/pdbsum/2fho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fho ProSAT]</span></td></tr>
{{STRUCTURE_2fho| PDB=2fho |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SF3B1_HUMAN SF3B1_HUMAN] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fho_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fho ConSurf].
<div style="clear:both"></div>


'''NMR solution structure of the human spliceosomal protein complex p14-SF3b155'''
==See Also==
 
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
 
__TOC__
==Disease==
</StructureSection>
Known disease associated with this structure: Immunodeficiency due to defect in MAPBP-interacting protein OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610389 610389]]
 
==About this Structure==
2FHO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHO OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Dohmae, N.]]
[[Category: Dohmae N]]
[[Category: Guntert, P.]]
[[Category: Guntert P]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kuwasako, K.]]
[[Category: Kuwasako K]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Seraphin B]]
[[Category: Seraphin, B.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rrm domain]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:54:43 2008''
Retrieved from "https://proteopedia.org/2fho"