2o2v: Difference between revisions

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New page: left|200px<br /> <applet load="2o2v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o2v, resolution 1.830Å" /> '''Crystal Structure ...
 
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[[Image:2o2v.gif|left|200px]]<br />
<applet load="2o2v" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2o2v, resolution 1.830&Aring;" />
'''Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)'''<br />


==About this Structure==
==Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)==
2O2V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2O2V OCA].  
<StructureSection load='2o2v' size='340' side='right'caption='[[2o2v]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2o2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2v OCA], [https://pdbe.org/2o2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2v RCSB], [https://www.ebi.ac.uk/pdbsum/2o2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>
 
==See Also==
*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Edwards A]]
[[Category: Delft, F.von.]]
[[Category: Filippakopoulos P]]
[[Category: Edwards, A.]]
[[Category: Knapp S]]
[[Category: Filippakopoulos, P.]]
[[Category: Savitsky P]]
[[Category: Knapp, S.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Savitsky, P.]]
[[Category: Von Delft F]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu, E.]]
[[Category: map kinase 5]]
[[Category: map/erk kinase kinase 3]]
[[Category: map2k5]]
[[Category: mapkkk3]]
[[Category: mek5]]
[[Category: mekk3]]
[[Category: mitogen activated protein kinase kinase 5]]
[[Category: mitogen activated protein kinase kinase kinase 3]]
[[Category: mkk5]]
[[Category: phox]]
[[Category: phox-domain]]
[[Category: prkmk5]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:05:54 2007''
Retrieved from "https://proteopedia.org/2o2v"