2gdd: Difference between revisions

(10 intermediate revisions by the same user not shown)

Line 1:

~~[[Image:2gdd.gif|left|200px]]~~

<!--

==Human beta II tryptase with inhibitor CRA-27592==

~~The line below this paragraph, containing~~ "~~STRUCTURE_2gdd~~"~~, creates the~~ "~~Structure Box~~" ~~on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

== Structural highlights ==

~~or the SCENE parameter~~ (~~which sets the initial~~ scene ~~displayed when~~ the ~~page~~ is ~~loaded~~),

<table><tr><td colspan='2'>[[2gdd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GDD FirstGlance]. <br>

~~or leave~~ the ~~SCENE parameter empty for the default display.~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr>

-->

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5AM:BENZYL+{(1S)-5-AMINO-1-[(S)-HYDROXY(5-{[4-(4-PHENYLBUTANOYL)PIPERAZIN-1-YL]METHYL}-1,2,4-OXADIAZOL-3-YL)METHYL]PENTYL}CARBAMATE'>5AM</scene></td></tr>

~~{{STRUCTURE_2gdd~~| ~~PDB~~=2gdd ~~| SCENE~~= }}

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdd OCA], [https://pdbe.org/2gdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gdd RCSB], [https://www.ebi.ac.uk/pdbsum/2gdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gdd ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/2gdd_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gdd ConSurf].

~~'''Human beta II tryptase with inhibitor CRA-27592'''~~

==See Also==

*[[Tryptase|Tryptase]]

__TOC__

==~~About this Structure~~==

</StructureSection>

~~2GDD is a~~ [[~~Single protein~~]] ~~structure of sequence from [http://en.wikipedia.org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDD OCA].~~

[[Category: Homo sapiens]]

[[Category: ~~Single protein]]~~

[[Category: Large Structures]]

~~[[Category: Tryptase~~]]

[[Category: Somoza JR]]

[[Category: Somoza~~, J R.]]~~

~~[[Category: Serine protease]~~]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA~~ ] ~~on Sun May 4 04:58:39 2008''~~

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2gdd.gif|left|200px]]
-<!--
+==Human beta II tryptase with inhibitor CRA-27592==
-The line below this paragraph, containing "STRUCTURE_2gdd", creates the "Structure Box" on the page.
+<StructureSection load='2gdd' size='340' side='right'caption='[[2gdd]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2gdd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GDD FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5AM:BENZYL+{(1S)-5-AMINO-1-[(S)-HYDROXY(5-{[4-(4-PHENYLBUTANOYL)PIPERAZIN-1-YL]METHYL}-1,2,4-OXADIAZOL-3-YL)METHYL]PENTYL}CARBAMATE'>5AM</scene></td></tr>
-{{STRUCTURE_2gdd|  PDB=2gdd  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdd OCA], [https://pdbe.org/2gdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gdd RCSB], [https://www.ebi.ac.uk/pdbsum/2gdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gdd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/2gdd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gdd ConSurf].
+<div style="clear:both"></div>
-'''Human beta II tryptase with inhibitor CRA-27592'''
+==See Also==
+*[[Tryptase|Tryptase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-GDD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDD OCA].
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Tryptase]]
+[[Category: Somoza JR]]
-[[Category: Somoza, J R.]]
-[[Category: Serine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:58:39 2008''