2oni: Difference between revisions

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New page: left|200px<br /> <applet load="2oni" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oni, resolution 2.20Å" /> '''Catalytic Domain of...
 
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[[Image:2oni.gif|left|200px]]<br />
<applet load="2oni" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2oni, resolution 2.20&Aring;" />
'''Catalytic Domain of the Human NEDD4-like E3 Ligase'''<br />


==About this Structure==
==Catalytic Domain of the Human NEDD4-like E3 Ligase==
2ONI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ONI OCA].  
<StructureSection load='2oni' size='340' side='right'caption='[[2oni]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2oni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oni OCA], [https://pdbe.org/2oni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oni RCSB], [https://www.ebi.ac.uk/pdbsum/2oni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oni ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NED4L_HUMAN NED4L_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:12911626</ref> <ref>PMID:15217910</ref> <ref>PMID:15489223</ref> <ref>PMID:15040001</ref> <ref>PMID:15496141</ref> <ref>PMID:15576372</ref> <ref>PMID:19144635</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2oni_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oni ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith CH]]
[[Category: Avvakumov, G.V.]]
[[Category: Avvakumov GV]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Butler-Cole, C.]]
[[Category: Butler-Cole C]]
[[Category: Dhe-Paganon, S.]]
[[Category: Dhe-Paganon S]]
[[Category: Edwards, A.M.]]
[[Category: Edwards AM]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Walker JR]]
[[Category: Walker, J.R.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Xue S]]
[[Category: Xue, S.]]
[[Category: NA]]
[[Category: alpha and beta protein (a + b)]]
[[Category: e3 ligase]]
[[Category: hect domain]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
[[Category: ubl-conjugation pathway]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:13:32 2007''
Retrieved from "https://proteopedia.org/2oni"