2opw: Difference between revisions
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New page: left|200px<br /> <applet load="2opw" size="450" color="white" frame="true" align="right" spinBox="true" caption="2opw, resolution 1.90Å" /> '''Crystal structure o... |
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== | ==Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)== | ||
<StructureSection load='2opw' size='340' side='right'caption='[[2opw]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2opw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opw OCA], [https://pdbe.org/2opw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opw RCSB], [https://www.ebi.ac.uk/pdbsum/2opw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PHYD1_HUMAN PHYD1_HUMAN] Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA. Isoform 2 and isoform 3 probably lack enzyme activity.<ref>PMID:21530488</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2opw_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2opw ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Dioxygenase 3D structures|Dioxygenase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bray | [[Category: Bray JE]] | ||
[[Category: Butler | [[Category: Butler D]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Kavanagh KL]] | ||
[[Category: Kavanagh | [[Category: McDonough MA]] | ||
[[Category: McDonough | [[Category: Ng SS]] | ||
[[Category: Ng | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Schofield CJ]] | ||
[[Category: Sundstrom M]] | |||
[[Category: Schofield | [[Category: Weigelt J]] | ||
[[Category: Sundstrom | [[Category: Zhang Z]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: Zhang | |||
[[Category: | |||
Latest revision as of 00:21, 28 December 2023
Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)
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