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{{STRUCTURE_2h0n|  PDB=2h0n  |  SCENE=  }}


'''Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC'''
==Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC==
 
<StructureSection load='2h0n' size='340' side='right'caption='[[2h0n]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
 
== Structural highlights ==
==Overview==
<table><tr><td colspan='2'>[[2h0n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H0N FirstGlance]. <br>
CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=XAL:[(1S,4R,6R)-6-HYDROXY-4-(ADENIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XAL</scene>, <scene name='pdbligand=XCL:[(1S,4R,6R)-6-HYDROXY-4-(CYTOSIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XCL</scene>, <scene name='pdbligand=XGL:[(1S,4R,6R)-6-HYDROXY-4-(GUANIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XGL</scene>, <scene name='pdbligand=XTL:[(1S,4R,6R)-6-HYDROXY-4-(THYMIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XTL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0n OCA], [https://pdbe.org/2h0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h0n RCSB], [https://www.ebi.ac.uk/pdbsum/2h0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h0n ProSAT]</span></td></tr>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0N OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18198873 18198873]
[[Category: Large Structures]]
[[Category: Meervelt, L Van.]]
[[Category: Robeyns K]]
[[Category: Robeyns, K.]]
[[Category: Van Meervelt L]]
[[Category: Cyclohexene nucleic acid]]
[[Category: Dna analogue]]
[[Category: Double helix]]
[[Category: Left-handed]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:43:55 2008''
Retrieved from "https://proteopedia.org/2h0n"