2p02: Difference between revisions

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New page: left|200px<br /> <applet load="2p02" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p02, resolution 1.21Å" /> '''Crystal structure o...
 
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[[Image:2p02.gif|left|200px]]<br />
<applet load="2p02" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2p02, resolution 1.21&Aring;" />
'''Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2'''<br />


==About this Structure==
==Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2==
2P02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL and SAM as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 2HJ2. Active as [http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2P02 OCA].  
<StructureSection load='2p02' size='340' side='right'caption='[[2p02]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2p02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hj2 2hj2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P02 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p02 OCA], [https://pdbe.org/2p02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p02 RCSB], [https://www.ebi.ac.uk/pdbsum/2p02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p02 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/2p02_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p02 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Methionine adenosyltransferase|Methionine adenosyltransferase]]
*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Methionine adenosyltransferase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C.H.]]
[[Category: Edwards A]]
[[Category: Delft, F.von.]]
[[Category: Gorrec F]]
[[Category: Edwards, A.]]
[[Category: Kavanagh KL]]
[[Category: Gorrec, F.]]
[[Category: Niessen FH]]
[[Category: Kavanagh, K.L.]]
[[Category: Oppermann U]]
[[Category: Niessen, F.H.]]
[[Category: Papagrigoriou E]]
[[Category: Oppermann, U.]]
[[Category: Rojkova A]]
[[Category: Papagrigoriou, E.]]
[[Category: Shafqat N]]
[[Category: Rojkova, A.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Shafqat, N.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt, J.]]
[[Category: CL]]
[[Category: SAM]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
[[Category: synthetase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:18:49 2007''

Latest revision as of 10:51, 30 August 2023

Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2

2p02, resolution 1.21Å

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