2p57: Difference between revisions
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New page: left|200px<br /> <applet load="2p57" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p57, resolution 1.800Å" /> '''GAP domain of ZNF2... |
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== | ==GAP domain of ZNF289, an ID1-regulated zinc finger protein== | ||
<StructureSection load='2p57' size='340' side='right'caption='[[2p57]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2p57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P57 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p57 OCA], [https://pdbe.org/2p57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p57 RCSB], [https://www.ebi.ac.uk/pdbsum/2p57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p57 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ARFG2_HUMAN ARFG2_HUMAN] GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.<ref>PMID:17760859</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p57_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p57 ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bochkarev | [[Category: Bochkarev A]] | ||
[[Category: Dimov | [[Category: Dimov S]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Landry | [[Category: Landry R]] | ||
[[Category: Park | [[Category: Park H]] | ||
[[Category: Shen L]] | |||
[[Category: Shen | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Tempel W]] | ||
[[Category: Tempel | [[Category: Tong Y]] | ||
[[Category: Tong | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Zhu H]] | ||
[[Category: Zhu | |||
Latest revision as of 10:54, 30 August 2023
GAP domain of ZNF289, an ID1-regulated zinc finger protein
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