2pgv: Difference between revisions

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New page: left|200px<br /> <applet load="2pgv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pgv, resolution 1.79Å" /> '''GTB C209A'''<br /> ...
 
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[[Image:2pgv.gif|left|200px]]<br />
<applet load="2pgv" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2pgv, resolution 1.79&Aring;" />
'''GTB C209A'''<br />


==Disease==
==GTB C209A==
Known disease associated with this structure: Blood group, ABO system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=110300 110300]]
<StructureSection load='2pgv' size='340' side='right'caption='[[2pgv]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2pgv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PGV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pgv OCA], [https://pdbe.org/2pgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pgv RCSB], [https://www.ebi.ac.uk/pdbsum/2pgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pgv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pg/2pgv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pgv ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2PGV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PGV OCA].
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Letts, J.A.]]
[[Category: Letts JA]]
[[Category: Schuman, B.]]
[[Category: Schuman B]]
[[Category: HG]]
[[Category: abo(h)]]
[[Category: blood group]]
[[Category: c209a]]
[[Category: glycosyltransferase]]
[[Category: gtb]]
[[Category: h-antigen]]
[[Category: rossmann fold]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:23:44 2007''
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