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[[Image:2hy3.gif|left|200px]]
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{{STRUCTURE_2hy3|  PDB=2hy3  |  SCENE=  }}
'''Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate'''


==Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate==
<StructureSection load='2hy3' size='340' side='right'caption='[[2hy3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HY3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy3 OCA], [https://pdbe.org/2hy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hy3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hy3 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hy3 TOPSAN]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/2hy3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hy3 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.


==Overview==
Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref>
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2HY3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY3 OCA].
</div>
<div class="pdbe-citations 2hy3" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
[[Category: Homo sapiens]]
== References ==
[[Category: Protein-tyrosine-phosphatase]]
<references/>
[[Category: Single protein]]
__TOC__
[[Category: Bera, A.]]
</StructureSection>
[[Category: Burley, S K.]]
[[Category: Large Structures]]
[[Category: Freeman, J C.]]
[[Category: Bera A]]
[[Category: Jin, X.]]
[[Category: Burley SK]]
[[Category: Min, T.]]
[[Category: Freeman JC]]
[[Category: Mu, H.]]
[[Category: Jin X]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Min T]]
[[Category: Reyes, C.]]
[[Category: Mu H]]
[[Category: Sauder, J M.]]
[[Category: Reyes C]]
[[Category: Shapiro, L.]]
[[Category: Sauder JM]]
[[Category: Smith, D.]]
[[Category: Shapiro L]]
[[Category: Wasserman, S R.]]
[[Category: Smith D]]
[[Category: Hydrolase]]
[[Category: Wasserman SR]]
[[Category: New york structural genomix research consortium]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:51:16 2008''

Latest revision as of 08:13, 13 August 2026

Crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate

2hy3, resolution 2.60Å

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