2q7z: Difference between revisions

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New page: left|200px<br /> <applet load="2q7z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q7z" /> '''Solution Structure of the 30 SCR domains of...
 
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[[Image:2q7z.gif|left|200px]]<br />
<applet load="2q7z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2q7z" />
'''Solution Structure of the 30 SCR domains of human Complement Receptor 1'''<br />


==Disease==
==Solution Structure of the 30 SCR domains of human Complement Receptor 1==
Known diseases associated with this structure: Blood group, Knops system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], CR1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], Malaria, severe, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], SLE susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]]
<StructureSection load='2q7z' size='340' side='right'caption='[[2q7z]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
2Q7Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [https://pdbe.org/2q7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [https://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN] Mediates cellular binding of particles and immune complexes that have activated complement.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q7z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q7z ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Furtado, P.B.]]
[[Category: Furtado PB]]
[[Category: Hammond, R.A.]]
[[Category: Hammond RA]]
[[Category: Huang, C.Y.]]
[[Category: Huang CY]]
[[Category: Ihyembe, D.]]
[[Category: Ihyembe D]]
[[Category: Marsh, H.C.]]
[[Category: Marsh HC]]
[[Category: Perkins, S.J.]]
[[Category: Perkins SJ]]
[[Category: blood group antigen]]
[[Category: complement]]
[[Category: complement pathway]]
[[Category: glycoprotein]]
[[Category: immune response]]
[[Category: immune system]]
[[Category: innate immunity]]
[[Category: membrane]]
[[Category: polymorphism]]
[[Category: pyrrolidone carboxylic acid]]
[[Category: receptor]]
[[Category: scr domain]]
[[Category: sushi]]
[[Category: transmembrane]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:30:49 2007''
Retrieved from "https://proteopedia.org/2q7z"