2r1z: Difference between revisions

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New page: left|200px<br /> <applet load="2r1z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r1z, resolution 2.100Å" /> '''Crystal Structure ...
 
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[[Image:2r1z.gif|left|200px]]<br />
<applet load="2r1z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2r1z, resolution 2.100&Aring;" />
'''Crystal Structure of the BARD1 BRCT Repeat'''<br />


==Disease==
==Crystal Structure of the BARD1 BRCT Repeat==
Known disease associated with this structure: Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601593 601593]]
<StructureSection load='2r1z' size='340' side='right'caption='[[2r1z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2r1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R1Z FirstGlance]. <br>
2R1Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2R1Z OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r1z OCA], [https://pdbe.org/2r1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r1z RCSB], [https://www.ebi.ac.uk/pdbsum/2r1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r1z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/2r1z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r1z ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Edwards, R.A.]]
[[Category: Edwards RA]]
[[Category: Glover, M.J.N.]]
[[Category: Glover MJN]]
[[Category: Lee, M.S.]]
[[Category: Lee MS]]
[[Category: Williams, R.S.]]
[[Category: Williams RS]]
[[Category: GOL]]
[[Category: ank repeat]]
[[Category: antitumor protein]]
[[Category: brct repeat]]
[[Category: disease mutation]]
[[Category: metal-binding]]
[[Category: nucleus]]
[[Category: polymorphism]]
[[Category: zinc]]
[[Category: zinc-finger]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:35:48 2007''
Retrieved from "https://proteopedia.org/2r1z"