2r4h: Difference between revisions

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New page: left|200px<br /> <applet load="2r4h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r4h, resolution 2.05Å" /> '''Crystal structure o...
 
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[[Image:2r4h.gif|left|200px]]<br />
<applet load="2r4h" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2r4h, resolution 2.05&Aring;" />
'''Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase'''<br />


==About this Structure==
==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==
2R4H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HIS as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].  
<StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith CH]]
[[Category: Cooper, C.]]
[[Category: Cooper C]]
[[Category: Delft, F.von.]]
[[Category: Doyle DA]]
[[Category: Doyle, D.A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A.M.]]
[[Category: Elkins JM]]
[[Category: Elkins, J.M.]]
[[Category: Hozjan V]]
[[Category: Hozjan, V.]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K.L.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Pike ACW]]
[[Category: Pike, A.C.W.]]
[[Category: Pilka ES]]
[[Category: Pilka, E.S.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: HIS]]
[[Category: alternative splicing]]
[[Category: atp-binding]]
[[Category: cell junction]]
[[Category: membrane associated guanylate kinase]]
[[Category: nucleotide-binding]]
[[Category: pdz]]
[[Category: phosphorylation]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
[[Category: tight junction]]
[[Category: transferase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:36:05 2007''
Retrieved from "https://proteopedia.org/2r4h"