2rcz: Difference between revisions

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New page: left|200px<br /> <applet load="2rcz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2rcz, resolution 1.700Å" /> '''Structure of the s...
 
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[[Image:2rcz.gif|left|200px]]<br />
<applet load="2rcz" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2rcz, resolution 1.700&Aring;" />
'''Structure of the second PDZ domain of ZO-1'''<br />


==About this Structure==
==Structure of the second PDZ domain of ZO-1==
2RCZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RCZ OCA].  
<StructureSection load='2rcz' size='340' side='right'caption='[[2rcz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rcz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcz OCA], [https://pdbe.org/2rcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcz RCSB], [https://www.ebi.ac.uk/pdbsum/2rcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rcz ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Lavie, A.]]
[[Category: Lavie A]]
[[Category: Lye, M.F.]]
[[Category: Lye MF]]
[[Category: cell junction]]
[[Category: domain-swapping]]
[[Category: membrane]]
[[Category: pdz]]
[[Category: phosphorylation]]
[[Category: protein binding]]
[[Category: sh3 domain]]
[[Category: tight junction]]
 
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Retrieved from "https://proteopedia.org/2rcz"