2j07: Difference between revisions

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[[Image:2j07.jpg|left|200px]]


<!--
==Thermus DNA photolyase with 8-HDF antenna chromophore==
The line below this paragraph, containing "STRUCTURE_2j07", creates the "Structure Box" on the page.
<StructureSection load='2j07' size='340' side='right'caption='[[2j07]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2j07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J07 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HDF:8-HYDROXY-10-(D-RIBO-2,3,4,5-TETRAHYDROXYPENTYL)-5-DEAZAISOALLOXAZINE'>HDF</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_2j07|  PDB=2j07  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j07 OCA], [https://pdbe.org/2j07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j07 RCSB], [https://www.ebi.ac.uk/pdbsum/2j07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j07 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHR_THET8 PHR_THET8] Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/2j07_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j07 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
X-ray crystallographic and functional analysis of the class I DNA photolyase from Thermus thermophilus revealed the binding of flavin mononucleotide (FMN) as an antenna chromophore. The binding mode of FMN closely coincides with the binding of a deazaflavin-like chromophore in the related class I DNA photolyase from Anacystis nidulans. Compared to the R46E mutant, which lacks a conserved arginine in the binding site for the antenna chromophore, the FMN-comprising holophotolyase exhibits an eightfold higher activity at 450 nm. The facile incorporation of the flavin cofactors 8-hydroxy-deazariboflavin and 8-iodo-8-demethyl-riboflavin into the binding site for the antenna chromophore paves the way for wavelength-tuning of the activity spectra of DNA photolyases by using synthetic flavins.


'''THERMUS DNA PHOTOLYASE WITH 8-HDF ANTENNA CHROMOPHORE'''
Natural and non-natural antenna chromophores in the DNA photolyase from Thermus thermophilus.,Klar T, Kaiser G, Hennecke U, Carell T, Batschauer A, Essen LO Chembiochem. 2006 Nov;7(11):1798-806. PMID:17051659<ref>PMID:17051659</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2J07 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J07 OCA].
<div class="pdbe-citations 2j07" style="background-color:#fffaf0;"></div>
[[Category: Deoxyribodipyrimidine photo-lyase]]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Thermus thermophilus]]
__TOC__
[[Category: Batschauer, A.]]
</StructureSection>
[[Category: Carell, T.]]
[[Category: Large Structures]]
[[Category: Essen, L O.]]
[[Category: Thermus thermophilus HB8]]
[[Category: Hennecke, U.]]
[[Category: Batschauer A]]
[[Category: Kaiser, G.]]
[[Category: Carell T]]
[[Category: Klar, T.]]
[[Category: Essen L-O]]
[[Category: 8-hdf]]
[[Category: Hennecke U]]
[[Category: Antenna chromophore]]
[[Category: Kaiser G]]
[[Category: Chromophore]]
[[Category: Klar T]]
[[Category: Dna binding protein]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Lyase]]
[[Category: Nucleotide-binding]]
[[Category: Photoreactivating enzyme]]
[[Category: Plasmid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:09:11 2008''

Latest revision as of 14:30, 13 December 2023

Thermus DNA photolyase with 8-HDF antenna chromophore

2j07, resolution 1.95Å

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