2jii: Difference between revisions

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[[Image:2jii.gif|left|200px]]


<!--
==Structure of vaccinia related kinase 3==
The line below this paragraph, containing "STRUCTURE_2jii", creates the "Structure Box" on the page.
<StructureSection load='2jii' size='340' side='right'caption='[[2jii]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jii]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JII FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
{{STRUCTURE_2jii|  PDB=2jii |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jii OCA], [https://pdbe.org/2jii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jii RCSB], [https://www.ebi.ac.uk/pdbsum/2jii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jii ProSAT]</span></td></tr>
 
</table>
'''STRUCTURE OF VACCINIA RELATED KINASE 3'''
== Function ==
 
[https://www.uniprot.org/uniprot/VRK3_HUMAN VRK3_HUMAN] Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.<ref>PMID:14645249</ref> <ref>PMID:19141289</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2JII is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JII OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jii_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jii ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bunkoczi G]]
[[Category: Bunkoczi, G.]]
[[Category: Burgess-Brown N]]
[[Category: Burgess-Brown, N.]]
[[Category: Cooper C]]
[[Category: Cooper, C.]]
[[Category: Edwards A]]
[[Category: Delft, F Von.]]
[[Category: Eswaran J]]
[[Category: Edwards, A.]]
[[Category: Fedorov O]]
[[Category: Eswaran, J.]]
[[Category: Keates T]]
[[Category: Fedorov, O.]]
[[Category: Knapp S]]
[[Category: Keates, T.]]
[[Category: Pike ACW]]
[[Category: Knapp, S.]]
[[Category: Salah E]]
[[Category: Pike, A C.W.]]
[[Category: Savitsky P]]
[[Category: Salah, E.]]
[[Category: Sobott F]]
[[Category: Savitsky, P.]]
[[Category: Sundstrom M]]
[[Category: Sobott, F.]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M.]]
[[Category: Uppenberg J]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt J]]
[[Category: Uppenberg, J.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Pseudo kinase domain]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Vaccinia related kinase]]
[[Category: Vrk3]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:58:06 2008''
Retrieved from "https://proteopedia.org/2jii"