2jv3: Difference between revisions

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[[Image:2jv3.gif|left|200px]]


<!--
==Ets-1 PNT domain (29-138) NMR structure ensemble==
The line below this paragraph, containing "STRUCTURE_2jv3", creates the "Structure Box" on the page.
<StructureSection load='2jv3' size='340' side='right'caption='[[2jv3]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bqv 1bqv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JV3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jv3 OCA], [https://pdbe.org/2jv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jv3 ProSAT]</span></td></tr>
{{STRUCTURE_2jv3|  PDB=2jv3 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETS1_MOUSE ETS1_MOUSE] Transcription factor.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/2jv3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jv3 ConSurf].
<div style="clear:both"></div>


'''Ets-1 PNT domain (29-138) NMR structure ensemble'''
==See Also==
 
*[[Ets1|Ets1]]
 
__TOC__
==Overview==
</StructureSection>
The Pointed (PNT) domain and an adjacent mitogen-activated protein (MAP) kinase phosphorylation site are defined by sequence conservation among a subset of ets transcription factors and are implicated in two regulatory strategies, protein interactions and posttranslational modifications, respectively. By using NMR, we have determined the structure of a 110-residue fragment of murine Ets-1 that includes the PNT domain and MAP kinase site. The Ets-1 PNT domain forms a monomeric five-helix bundle. The architecture is distinct from that of any known DNA- or protein-binding module, including the helix-loop-helix fold proposed for the PNT domain of the ets protein TEL. The MAP kinase site is in a highly flexible region of both the unphosphorylated and phosphorylated forms of the Ets-1 fragment. Phosphorylation alters neither the structure nor monomeric state of the PNT domain. These results suggest that the Ets-1 PNT domain functions in heterotypic protein interactions and support the possibility that target recognition is coupled to structuring of the MAP kinase site.
[[Category: Large Structures]]
 
==About this Structure==
2JV3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bqv 1bqv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JV3 OCA].
 
==Reference==
Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site., Slupsky CM, Gentile LN, Donaldson LW, Mackereth CD, Seidel JJ, Graves BJ, McIntosh LP, Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12129-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9770451 9770451]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Kang H]]
[[Category: Kang, H.]]
[[Category: Lawrence MP]]
[[Category: Lawrence, M P.]]
[[Category: Lee GM]]
[[Category: Lee, G M.]]
[[Category: Schaerpf M]]
[[Category: Schaerpf, M.]]
[[Category: Slupsky CM]]
[[Category: Slupsky, C M.]]
[[Category: Alpha-helical bundle]]
[[Category: Dna-binding]]
[[Category: Map kinase phosphorylation site]]
[[Category: Nucleus]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:19:26 2008''

Latest revision as of 19:06, 29 May 2024

Ets-1 PNT domain (29-138) NMR structure ensemble

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