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[[Image:2jwq.jpg|left|200px]]


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==G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study==
The line below this paragraph, containing "STRUCTURE_2jwq", creates the "Structure Box" on the page.
<StructureSection load='2jwq' size='340' side='right'caption='[[2jwq]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jwq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MM0:N,N-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene></td></tr>
{{STRUCTURE_2jwq|  PDB=2jwq  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [https://pdbe.org/2jwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB], [https://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwq ProSAT]</span></td></tr>
 
</table>
'''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study'''
<div style="background-color:#fffaf0;">
 
== Publication Abstract from PubMed ==
 
==Overview==
The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.
The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.


==About this Structure==
G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study.,Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP ChemMedChem. 2007 May;2(5):655-66. PMID:17385760<ref>PMID:17385760</ref>
2JWQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17385760 17385760]
</div>
[[Category: Single protein]]
<div class="pdbe-citations 2jwq" style="background-color:#fffaf0;"></div>
[[Category: Guittat, L.]]
== References ==
[[Category: Hounsou, C.]]
<references/>
[[Category: Jourdan, M.]]
__TOC__
[[Category: Mergny, J L.]]
</StructureSection>
[[Category: Monchaud, D.]]
[[Category: Large Structures]]
[[Category: Saettel, N.]]
[[Category: Guittat L]]
[[Category: Teulade-Fichou, M.]]
[[Category: Hounsou C]]
[[Category: Dna]]
[[Category: Jourdan M]]
[[Category: G-quadruplex]]
[[Category: Mergny JL]]
[[Category: Quinacridine]]
[[Category: Monchaud D]]
[[Category: Telomerase inhibitor]]
[[Category: Saettel N]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:21:40 2008''
[[Category: Teulade-Fichou M]]

Latest revision as of 12:49, 20 December 2023

G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study

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