1bhs: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /> <applet load="1bhs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bhs, resolution 2.20Å" /> '''HUMAN ESTROGENIC 17...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(25 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1bhs.gif|left|200px]]<br />
<applet load="1bhs" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bhs, resolution 2.20&Aring;" />
'''HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE'''<br />


==Overview==
==HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE==
BACKGROUND: The principal human estrogen, 17 beta-estradiol, is a potent, stimulator of certain endocrine-dependent forms of breast cancer. Because, human estrogenic 17 beta-hydroxysteroid dehydrogenase (type I 17 beta-HSD), catalyzes the last step in the biosynthesis of 17 beta-estradiol from the, less potent estrogen, estrone, it is an attractive target for the design, of inhibitors of estrogen production and tumor growth. This human enzyme, shares less than 15% sequence identity with a bacterial 3 alpha,20, beta-HSD, for which the three-dimensional structure is known. The amino, acid sequence of 17 beta-HSD also differs from that of bacterial 3, alpha,20 beta-HSD by two insertions (of 11 and 14 residues) and 52, additional residues at the C terminus. RESULTS: The 2.20 A resolution, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7663947 (full description)]]
<StructureSection load='1bhs' size='340' side='right'caption='[[1bhs]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BHS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bhs OCA], [https://pdbe.org/1bhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bhs RCSB], [https://www.ebi.ac.uk/pdbsum/1bhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bhs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/1bhs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bhs ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1BHS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BHS OCA]].
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution., Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX, Structure. 1995 May 15;3(5):503-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7663947 7663947]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ghosh, D.]]
[[Category: Ghosh D]]
[[Category: estrogen]]
[[Category: human placental 17beta-hsd]]
[[Category: human type i 17beta-hsd]]
[[Category: oxidoreductase]]
[[Category: short-chain dehydrogenase]]
[[Category: steroid dehydrogenase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:10:10 2007''
Retrieved from "https://proteopedia.org/1bhs"